Scientific Advisor
Dr. Glorioso began his academic career at the University of Michigan Medical School where he became Professor of Microbiology and Immunology and Assistant Dean for Research and Graduate Studies. In 1989, Dr. Glorioso moved to the University of Pittsburgh School of Medicine to become the William S. McElroy Professor of Biochemistry and Chairman of the Department of Molecular Genetics and Biochemistry, a position he held until 2009. He continues to be a professor in this department.
Dr. Glorioso has established a 40-year history of research related to the basic pathobiology, immunology and genetics of herpes simplex virus (HSV). His contributions to the field include defining antiviral immune responses to infection, the genetics of viral pathogenesis and latency, and mechanisms of viral infection. Furthermore, he has been a pioneer in the design and application of HSV gene vectors for the treatment of nervous system diseases such as peripheral neuropathies, chronic pain, and brain tumors. He continues to be a worldwide leader in the HSV gene vector field through the creation of innovative gene vectors and the development of manufacturing methods for human clinical trials.
Dr. Glorioso has served as a member of the Recombinant DNA Advisory Committee (RAC), NIH (1994-1996); NIH Steering Committee of the National Gene Vector Laboratory (NGVL) (1995-2006); Member, NIH Steering Committee of the National Gene Vector Biorepository (2006- ); Founder, Member of the Board of Directors, Treasurer, Vice President, President, American Society of Gene and Cell Therapy (ASGCT); President, Association of Medical School Microbiology and Immunology Chairs (1999); National Steering Committee for the American Alliance for Cancer Gene Therapy (2006-) and Chair of ACGT Scientific Advisory Board (2014-). Dr. Glorioso was elected Fellow of the American Society of Microbiology (1991); Vectors/Pittsburgh – Man of the Year in Technology (1996); Elected to Who’s Who in America (1999); Elected Fellow of the American Association for the Advancement of Science (2003); 2007 Elected American Men and Woman of Science, Awarded the Paradigm Builder Lectureship by International Society of Neuro-virology (2010) and Human Gene Therapy: Gene Therapy Pioneer Award (2014).
Dr. Glorioso founded the Nature Journal Gene Therapy where he served as editor for 22 years and he is a member of the editorial board of Molecular Therapy. Dr. Glorioso co-founded several biotech companies that include Genvec Inc., Nuvovec srl and most recently Switch Bio, a neuromodulation company and Oncorus, Inc. a Cambridge based company dedicated to the use of oncolytic HSV for immunotherapy of cancer.