Armed oHSV Vector

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  • Robust anti-tumor effect following direct injection of unarmed Oncorus oHSV

  • Even greater tumor regression with armed Oncorus oHSV

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  • Modest abscopal response observed with unarmed oHSV

  • Robust abscopal effect observed in non-injected tumor with single immune payload

A20 flank tumor model demonstrates that armed oHSV induces robust oncolysis in injected tumor (top panel) and potent abscopal response in uninjected tumor (lower panel).